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cFMS Tyrosine kinase in complex with 5-Cyano-furan-2-carboxylic acid [4-(4-methyl-piperazin-1-yl)-2-piperidin-1-yl-phenyl]-amide

X-ray diffraction
2.4Å resolution
PDB entry 3krl coloured by chain, front view.
PDB entry 3krl coloured by chain, side view.
PDB entry 3krl coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Fibroblast growth factor receptor 1, Macrophage colony-stimulating factor 1 receptor
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Multimeric state: monomeric
Accessible surface area: 13275.03 Å2
Buried surface area: 92.1 Å2
Dissociation area: 46.05 Å2
Dissociation energy (ΔGdiss): 4.11 kcal/mol
Dissociation entropy (TΔSdiss): 0.47 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139511

Macromolecules

Fibroblast growth factor receptor 1; Macrophage colony-stimulating factor 1 receptor
Chain: A
Length: 335 amino acids
Theoretical weight: 38.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P07333 (Residues: 538-678, 686-686, 753-922; Coverage: 33%)
  • Canonical: P11362 (Residues: 577-583, 585-597; Coverage: 3%)
    • nullnull
Gene names: BFGFR, CEK, CSF1R, FGFBR, FGFR1, FLG, FLT2, FMS, HBGFR
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Fibroblast growth factor receptor 1 in PDB entry 3krl, assembly 1, front view.
Fibroblast growth factor receptor 1 in PDB entry 3krl, assembly 1, side view.
Fibroblast growth factor receptor 1 in PDB entry 3krl, assembly 1, top view.
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