PDBe 3krk

X-ray diffraction
2.4Å resolution

X-ray crystal structure of arachidonic acid bound in the cyclooxygenase channel of L531F murine COX-2

Released:
Source organism: Mus musculus
Primary publication:
Structural basis of fatty acid substrate binding to cyclooxygenase-2.
J. Biol. Chem. 285 22152-63 (2010)
PMID: 20463020

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin G/H synthase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 591 amino acids
Theoretical weight: 67.97 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q05769 (Residues: 20-604; Coverage: 100%)
Gene names: Cox-2, Cox2, Pghs-b, Ptgs2, Tis10
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: I222
Unit cell:
a: 120.79Å b: 133.04Å c: 180.654Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.179 0.228
Expression system: Spodoptera frugiperda