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Crystal structure of the C-terminal kinase domain of msk1 in complex with AMP-PNP

X-ray diffraction
2.4Å resolution
PDB entry 3kn5 coloured by chain, front view.
PDB entry 3kn5 coloured by chain, side view.
PDB entry 3kn5 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ribosomal protein S6 kinase alpha-5
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Multimeric state: monomeric
Accessible surface area: 14230.83 Å2
Buried surface area: 819.32 Å2
Dissociation area: 409.66 Å2
Dissociation energy (ΔGdiss): -1.79 kcal/mol
Dissociation entropy (TΔSdiss): 5.46 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131072
Assembly 2
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Assembly Name: Ribosomal protein S6 kinase alpha-5
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Multimeric state: monomeric
Accessible surface area: 14542.77 Å2
Buried surface area: 758.63 Å2
Dissociation area: 379.31 Å2
Dissociation energy (ΔGdiss): -2.81 kcal/mol
Dissociation entropy (TΔSdiss): 5.4 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131072

Macromolecules

Ribosomal protein S6 kinase alpha-5
Chains: A, B
Length: 325 amino acids
Theoretical weight: 37.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75582 (Residues: 414-738; Coverage: 41%)
Gene names: MSK1, RPS6KA5
Pfam: Protein kinase domain
InterPro:
CATH:
Ribosomal protein S6 kinase alpha-5 in PDB entry 3kn5, assembly 1, front view.
Ribosomal protein S6 kinase alpha-5 in PDB entry 3kn5, assembly 1, side view.
Ribosomal protein S6 kinase alpha-5 in PDB entry 3kn5, assembly 1, top view.
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