PDBe 3kmm

X-ray diffraction
2.8Å resolution

Structure of human LCK kinase with a small molecule inhibitor

Released:
Source organism: Homo sapiens
Entry authors: Graves BJ, Surgenor A, Harris W, Smith I, Orchard S, Flotow H, Murray E

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Lck Chain: A
Molecule details ›
Chain: A
Length: 288 amino acids
Theoretical weight: 33.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06239 (Residues: 229-509; Coverage: 55%)
Gene name: LCK
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: Cu FINE FOCUS
Spacegroup: P212121
Unit cell:
a: 42.579Å b: 74.16Å c: 92.85Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.167 0.165 0.223
Expression system: Spodoptera frugiperda