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Structure of PKA with a protein Kinase B-selective inhibitor.

X-ray diffraction
1.8Å resolution
PDB entry 3kkv coloured by chain, front view.
PDB entry 3kkv coloured by chain, side view.
PDB entry 3kkv coloured by chain, top view.
Source organism: Bos taurus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: cAMP-dependent protein kinase catalytic subunit alpha
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Multimeric state: hetero dimer
Accessible surface area: 16658.12 Å2
Buried surface area: 2054.16 Å2
Dissociation area: 1,027.08 Å2
Dissociation energy (ΔGdiss): 3.78 kcal/mol
Dissociation entropy (TΔSdiss): 9.22 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132596

Macromolecules

cAMP-dependent protein kinase catalytic subunit alpha
Chain: A
Length: 350 amino acids
Theoretical weight: 40.79 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00517 (Residues: 2-351; Coverage: 100%)
Gene name: PRKACA
Pfam: Protein kinase domain
InterPro:
CATH:
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 3kkv, assembly 1, front view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 3kkv, assembly 1, side view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 3kkv, assembly 1, top view.
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PKI kinase inhibitor
Chain: I
Length: 20 amino acids
Theoretical weight: 2.23 KDa
Source organism: Bos taurus
Expression system: Not provided
InterPro: cAMP-dependent protein kinase inhibitor
PKI kinase inhibitor in PDB entry 3kkv, assembly 1, front view.
PKI kinase inhibitor in PDB entry 3kkv, assembly 1, side view.
PKI kinase inhibitor in PDB entry 3kkv, assembly 1, top view.
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