› 3kkc

X-ray diffraction
2.5Å resolution

The crystal structure OF TetR transcriptional regulator from Streptococcus agalactiae 2603V

Released:
DOI: 10.2210/pdb3kkc/pdb
PDB entry 3kkc coloured by chain, front view.
PDB entry 3kkc coloured by chain, side view.
PDB entry 3kkc coloured by chain, top view.
Source organism: Streptococcus agalactiae 2603V/R
Entry authors: Tan K, Hatzos C, Morgan T, Clancy S, Joachimiak A, Midwest Center for Structural Genomics (MCSG)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190271 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH tetR-type domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 177 amino acids
Theoretical weight: 21.47 KDa
Source organism: Streptococcus agalactiae 2603V/R
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9F8C4 (Residues: 1-174; Coverage: 100%)
Gene names: AX245_00015, C4618_01335, C6N07_07300, NCTC8184_02037, NCTC8185_00432, WA04_03510, dhaS_1, dhaS_2
Sequence domains:
Structure domains: Tetracycline Repressor, domain 2

Ligands and Environments

2 bound ligands:
Ligand NI 4 x NI
Ligand IMD 12 x IMD
1 modified residue:
Ligand MSE 12 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 44.351Å b: 128.681Å c: 74.566Å
α: 90° β: 103.23° γ: 90°
R-values:
R R work R free
0.212 0.208 0.279
Expression system: Escherichia coli

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