Function and Biology

Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: Ras protein signal transduction
Cellular component: not assigned

GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00017
Domain description: SH2 domain
Occurring in:
  1. Growth factor receptor-bound protein 2
1 copy of Pfam domain PF00017 (SH2 domain) in Growth factor receptor-bound protein 2 in PDB 3kfj.

InterPro InterPro annotations
IPR000980
Domain description: SH2 domain
Occurring in:
  1. Growth factor receptor-bound protein 2
IPR036860
Domain description: SH2 domain superfamily
Occurring in:
  1. Growth factor receptor-bound protein 2
IPR030219
Domain description: Growth factor receptor-bound protein 2
Occurring in:
  1. Growth factor receptor-bound protein 2

Structure domain

CATH CATH domain
3.30.505.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: SHC Adaptor Protein
Homology: SHC Adaptor Protein
Occurring in:
  1. Growth factor receptor-bound protein 2
1 copy of CATH domain 3.30.505.10 (SHC Adaptor Protein) in Growth factor receptor-bound protein 2 in PDB 3kfj.