PDBe 3kck

X-ray diffraction
2.2Å resolution

A Novel Chemotype of Kinase Inhibitors


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein kinase JAK2 Chain: A
Molecule details ›
Chain: A
Length: 313 amino acids
Theoretical weight: 36.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: O60674 (Residues: 842-1132; Coverage: 26%)
Gene name: JAK2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2221
Unit cell:
a: 95.156Å b: 100.803Å c: 67.621Å
α: 90° β: 90° γ: 90°
R R work R free
0.244 0.225 0.296
Expression system: Spodoptera frugiperda