PDBe 3kcf

X-ray diffraction
2.8Å resolution

Crystal structure of TGFbRI complexed with a pyrazolone inhibitor

Released:
Source organism: Homo sapiens
Primary publication:
Pyrazolone based TGFbetaR1 kinase inhibitors.
Bioorg. Med. Chem. Lett. 20 326-9 (2010)
PMID: 19914068

Function and Biology Details

Reaction catalysed:
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TGF-beta receptor type-1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 342 amino acids
Theoretical weight: 38.92 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P36897 (Residues: 162-503; Coverage: 73%)
Gene names: ALK5, SKR4, TGFBR1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: C2221
Unit cell:
a: 174.025Å b: 249.076Å c: 138.011Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.235 0.278
Expression system: Spodoptera frugiperda