EC 2.3.2.23: E2 ubiquitin-conjugating enzyme
Reaction catalysed:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
Systematic name:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
Alternative Name(s):
- UBC
- Ubiquitin-carrier-protein E2
- Ubiquitin-conjugating enzyme E2
GO terms
Biochemical function:
Biological process:
- positive regulation of tumor necrosis factor-mediated signaling pathway
- protein K48-linked ubiquitination
- positive regulation of type I interferon-mediated signaling pathway
- cellular response to interferon-beta
- protein modification by small protein conjugation
- regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
- free ubiquitin chain polymerization
- positive regulation of peptidyl-threonine phosphorylation
- ubiquitin-dependent protein catabolic process
- protein polyubiquitination
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
IPR042599
Domain description:
Vertebrate ubiquitin-conjugating enzyme E2 K, UBA domain
Occurring in:
Occurring in:
Structure domains
CATH domains
3.10.20.90
Class:
Alpha Beta
Architecture:
Roll
Topology:
Ubiquitin-like (UB roll)
Homology:
Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
1.10.8.10
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
Helicase, Ruva Protein; domain 3
Homology:
DNA helicase RuvA subunit, C-terminal domain
Occurring in:
