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Cathepsin B in complex with stefin A

Source organism: Homo sapiens
Biochemical function: peptidase inhibitor activity
Biological process: cell-cell adhesion
Cellular component: peptidase inhibitor complex

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EC 3.4.22.1: Cathepsin B

Reaction catalysed:
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.
Alternative Name(s):
  • Cathepsin B1
  • Cathepsin II

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00031
Domain description: Cystatin domain
Occurring in:
  1. Cystatin-A
The deposited structure of PDB entry 3k9m contains 2 copies of Pfam domain PF00031 (Cystatin domain) in Cystatin-A. Showing 1 copy in chain B [auth C].

PF00112
Domain description: Papain family cysteine protease
Occurring in:
  1. Cathepsin B
The deposited structure of PDB entry 3k9m contains 2 copies of Pfam domain PF00112 (Papain family cysteine protease) in Cathepsin B. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001713
Domain description: Proteinase inhibitor I25A, stefin
Occurring in:
  1. Cystatin-A
IPR000668
Domain description: Peptidase C1A, papain C-terminal
Occurring in:
  1. Cathepsin B
IPR000010
Domain description: Cystatin domain
Occurring in:
  1. Cystatin-A
IPR018073
Domain description: Proteinase inhibitor I25, cystatin, conserved site
Occurring in:
  1. Cystatin-A
IPR046350
Domain description: Cystatin superfamily
Occurring in:
  1. Cystatin-A
IPR025661
Domain description: Cysteine peptidase, asparagine active site
Occurring in:
  1. Cathepsin B
IPR025660
Domain description: Cysteine peptidase, histidine active site
Occurring in:
  1. Cathepsin B
IPR000169
Domain description: Cysteine peptidase, cysteine active site
Occurring in:
  1. Cathepsin B
IPR013128
Domain description: Peptidase C1A
Occurring in:
  1. Cathepsin B
IPR038765
Domain description: Papain-like cysteine peptidase superfamily
Occurring in:
  1. Cathepsin B

Structure domains

CATH CATH domains
3.10.450.10
Class: Alpha Beta
Architecture: Roll
Topology: Nuclear Transport Factor 2; Chain: A,
Homology: Nuclear Transport Factor 2; Chain: A,
Occurring in:
  1. Cystatin-A
The deposited structure of PDB entry 3k9m contains 2 copies of CATH domain 3.10.450.10 (Nuclear Transport Factor 2; Chain: A,) in Cystatin-A. Showing 1 copy in chain B [auth C].
3.90.70.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Cathepsin B; Chain A
Homology: Cysteine proteinases
Occurring in:
  1. Cathepsin B
The deposited structure of PDB entry 3k9m contains 2 copies of CATH domain 3.90.70.10 (Cathepsin B; Chain A) in Cathepsin B. Showing 1 copy in chain A.

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