PDBe 3jzc

X-ray diffraction
2.5Å resolution

Crystal Structure of TR-beta bound to the selective thyromimetic TRIAC


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Thyroid hormone receptor beta Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 30.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P10828 (Residues: 202-461; Coverage: 56%)
Gene names: ERBA2, NR1A2, THR1, THRB
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU ULTRAX 18
Spacegroup: P3121
Unit cell:
a: 68.781Å b: 68.781Å c: 131.013Å
α: 90° β: 90° γ: 120°
R R work R free
0.2 0.198 0.246
Expression system: Escherichia coli