PDBe 3juh

X-ray diffraction
1.66Å resolution

Crystal structure of a mutant of human protein kinase CK2alpha with altered cosubstrate specificity

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 335 amino acids
Theoretical weight: 40.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-335; Coverage: 86%)
  • Best match: P68400-2 (Residues: 1-199)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: P43
Unit cell:
a: 71.368Å b: 71.368Å c: 126.467Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.158 0.156 0.218
Expression system: Escherichia coli