› › Structure analysis

3D structure determination of the human*U4/U6.U5* tri-snRNP complex

Electron Microscopy
7Å resolution
PDB entry 3jcr coloured by chain, front view.
PDB entry 3jcr coloured by chain, side view.
PDB entry 3jcr coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero 36-mer (preferred)
Entry contents: 26 distinct polypeptide molecules
3 distinct RNA molecules

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: hetero 36-mer
PDBe Complex ID: PDB-CPX-128861

Macromolecules

Pre-mRNA-processing factor 6
Chain: G
Length: 941 amino acids
Theoretical weight: 107.09 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O94906 (Residues: 1-941; Coverage: 100%)
Gene names: C20orf14, PRPF6
Pfam:
InterPro:
Pre-mRNA-processing factor 6 in PDB entry 3jcr, assembly 1, front view.
Pre-mRNA-processing factor 6 in PDB entry 3jcr, assembly 1, side view.
Pre-mRNA-processing factor 6 in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

U5 small nuclear ribonucleoprotein 40 kDa protein
Chain: D
Length: 357 amino acids
Theoretical weight: 39.36 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q96DI7 (Residues: 1-357; Coverage: 100%)
Gene names: PRP8BP, SFP38, SNRNP40, WDR57
Pfam: WD domain, G-beta repeat
InterPro:
U5 small nuclear ribonucleoprotein 40 kDa protein in PDB entry 3jcr, assembly 1, front view.
U5 small nuclear ribonucleoprotein 40 kDa protein in PDB entry 3jcr, assembly 1, side view.
U5 small nuclear ribonucleoprotein 40 kDa protein in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

U5 small nuclear ribonucleoprotein 200 kDa helicase
Chain: C
Length: 2136 amino acids
Theoretical weight: 244.82 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O75643 (Residues: 1-2136; Coverage: 100%)
Gene names: ASCC3L1, BRR2, HELIC2, KIAA0788, SNRNP200
Pfam:
InterPro:
U5 small nuclear ribonucleoprotein 200 kDa helicase in PDB entry 3jcr, assembly 1, front view.
U5 small nuclear ribonucleoprotein 200 kDa helicase in PDB entry 3jcr, assembly 1, side view.
U5 small nuclear ribonucleoprotein 200 kDa helicase in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

Thioredoxin-like protein 4A
Chain: E
Length: 142 amino acids
Theoretical weight: 16.81 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P83876 (Residues: 1-142; Coverage: 100%)
Gene names: DIM1, TXNL4, TXNL4A
Pfam: Mitosis protein DIM1
InterPro:
Thioredoxin-like protein 4A in PDB entry 3jcr, assembly 1, front view.
Thioredoxin-like protein 4A in PDB entry 3jcr, assembly 1, side view.
Thioredoxin-like protein 4A in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

Pre-mRNA-processing-splicing factor 8
Chain: A
Length: 2335 amino acids
Theoretical weight: 273.97 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q6P2Q9 (Residues: 1-2335; Coverage: 100%)
Gene names: PRPC8, PRPF8
Pfam:
InterPro:
Pre-mRNA-processing-splicing factor 8 in PDB entry 3jcr, assembly 1, front view.
Pre-mRNA-processing-splicing factor 8 in PDB entry 3jcr, assembly 1, side view.
Pre-mRNA-processing-splicing factor 8 in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

Probable ATP-dependent RNA helicase DDX23
Chain: F
Length: 820 amino acids
Theoretical weight: 95.79 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9BUQ8 (Residues: 1-820; Coverage: 100%)
Gene name: DDX23
Pfam:
InterPro:
Probable ATP-dependent RNA helicase DDX23 in PDB entry 3jcr, assembly 1, front view.
Probable ATP-dependent RNA helicase DDX23 in PDB entry 3jcr, assembly 1, side view.
Probable ATP-dependent RNA helicase DDX23 in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

116 kDa U5 small nuclear ribonucleoprotein component
Chain: B
Length: 972 amino acids
Theoretical weight: 109.56 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q15029 (Residues: 1-972; Coverage: 100%)
Gene names: EFTUD2, KIAA0031, SNRP116
Pfam:
InterPro:
116 kDa U5 small nuclear ribonucleoprotein component in PDB entry 3jcr, assembly 1, front view.
116 kDa U5 small nuclear ribonucleoprotein component in PDB entry 3jcr, assembly 1, side view.
116 kDa U5 small nuclear ribonucleoprotein component in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

Small nuclear ribonucleoprotein-associated proteins B and B'
Chains: O, o
Length: 240 amino acids
Theoretical weight: 24.64 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P14678 (Residues: 1-240; Coverage: 100%)
Gene names: COD, SNRPB, SNRPB1
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein-associated proteins B and B' in PDB entry 3jcr, assembly 1, front view.
Small nuclear ribonucleoprotein-associated proteins B and B' in PDB entry 3jcr, assembly 1, side view.
Small nuclear ribonucleoprotein-associated proteins B and B' in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

Small nuclear ribonucleoprotein Sm D1
Chains: P, p
Length: 119 amino acids
Theoretical weight: 13.31 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62314 (Residues: 1-119; Coverage: 100%)
Gene name: SNRPD1
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein Sm D1 in PDB entry 3jcr, assembly 1, front view.
Small nuclear ribonucleoprotein Sm D1 in PDB entry 3jcr, assembly 1, side view.
Small nuclear ribonucleoprotein Sm D1 in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

Small nuclear ribonucleoprotein Sm D2
Chains: Q, q
Length: 118 amino acids
Theoretical weight: 13.55 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62316 (Residues: 1-118; Coverage: 100%)
Gene names: SNRPD1, SNRPD2
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein Sm D2 in PDB entry 3jcr, assembly 1, front view.
Small nuclear ribonucleoprotein Sm D2 in PDB entry 3jcr, assembly 1, side view.
Small nuclear ribonucleoprotein Sm D2 in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

Small nuclear ribonucleoprotein Sm D3
Chains: R, r
Length: 126 amino acids
Theoretical weight: 13.94 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62318 (Residues: 1-126; Coverage: 100%)
Gene name: SNRPD3
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein Sm D3 in PDB entry 3jcr, assembly 1, front view.
Small nuclear ribonucleoprotein Sm D3 in PDB entry 3jcr, assembly 1, side view.
Small nuclear ribonucleoprotein Sm D3 in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

Small nuclear ribonucleoprotein E
Chains: S, s
Length: 92 amino acids
Theoretical weight: 10.82 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62304 (Residues: 1-92; Coverage: 100%)
Gene name: SNRPE
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein E in PDB entry 3jcr, assembly 1, front view.
Small nuclear ribonucleoprotein E in PDB entry 3jcr, assembly 1, side view.
Small nuclear ribonucleoprotein E in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

Small nuclear ribonucleoprotein F
Chains: T, t
Length: 86 amino acids
Theoretical weight: 9.73 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62306 (Residues: 1-86; Coverage: 100%)
Gene names: PBSCF, SNRPF
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein F in PDB entry 3jcr, assembly 1, front view.
Small nuclear ribonucleoprotein F in PDB entry 3jcr, assembly 1, side view.
Small nuclear ribonucleoprotein F in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

Small nuclear ribonucleoprotein G
Chains: U, u
Length: 76 amino acids
Theoretical weight: 8.51 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62308 (Residues: 1-76; Coverage: 100%)
Gene names: PBSCG, SNRPG
Pfam: LSM domain
InterPro:
Small nuclear ribonucleoprotein G in PDB entry 3jcr, assembly 1, front view.
Small nuclear ribonucleoprotein G in PDB entry 3jcr, assembly 1, side view.
Small nuclear ribonucleoprotein G in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

U6 snRNA-associated Sm-like protein LSm8
Chain: 8
Length: 96 amino acids
Theoretical weight: 10.41 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O95777 (Residues: 1-96; Coverage: 100%)
Gene name: LSM8
Pfam: LSM domain
InterPro:
U6 snRNA-associated Sm-like protein LSm8 in PDB entry 3jcr, assembly 1, front view.
U6 snRNA-associated Sm-like protein LSm8 in PDB entry 3jcr, assembly 1, side view.
U6 snRNA-associated Sm-like protein LSm8 in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

U6 snRNA-associated Sm-like protein LSm6
Chain: 6
Length: 80 amino acids
Theoretical weight: 9.14 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62312 (Residues: 1-80; Coverage: 100%)
Gene name: LSM6
Pfam: LSM domain
InterPro:
U6 snRNA-associated Sm-like protein LSm6 in PDB entry 3jcr, assembly 1, front view.
U6 snRNA-associated Sm-like protein LSm6 in PDB entry 3jcr, assembly 1, side view.
U6 snRNA-associated Sm-like protein LSm6 in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

U6 snRNA-associated Sm-like protein LSm5
Chain: 5
Length: 91 amino acids
Theoretical weight: 9.95 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y4Y9 (Residues: 1-91; Coverage: 100%)
Gene name: LSM5
Pfam: LSM domain
InterPro:
U6 snRNA-associated Sm-like protein LSm5 in PDB entry 3jcr, assembly 1, front view.
U6 snRNA-associated Sm-like protein LSm5 in PDB entry 3jcr, assembly 1, side view.
U6 snRNA-associated Sm-like protein LSm5 in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

U6 snRNA-associated Sm-like protein LSm4
Chain: 4
Length: 139 amino acids
Theoretical weight: 15.38 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y4Z0 (Residues: 1-139; Coverage: 100%)
Gene name: LSM4
Pfam: LSM domain
InterPro:
U6 snRNA-associated Sm-like protein LSm4 in PDB entry 3jcr, assembly 1, front view.
U6 snRNA-associated Sm-like protein LSm4 in PDB entry 3jcr, assembly 1, side view.
U6 snRNA-associated Sm-like protein LSm4 in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

U6 snRNA-associated Sm-like protein LSm3
Chain: 3
Length: 102 amino acids
Theoretical weight: 11.86 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P62310 (Residues: 1-102; Coverage: 100%)
Gene names: LSM3, MDS017
Pfam: LSM domain
InterPro:
U6 snRNA-associated Sm-like protein LSm3 in PDB entry 3jcr, assembly 1, front view.
U6 snRNA-associated Sm-like protein LSm3 in PDB entry 3jcr, assembly 1, side view.
U6 snRNA-associated Sm-like protein LSm3 in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

U6 snRNA-associated Sm-like protein LSm2
Chain: 2
Length: 95 amino acids
Theoretical weight: 10.85 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9Y333 (Residues: 1-95; Coverage: 100%)
Gene names: C6orf28, G7B, LSM2
Pfam: LSM domain
InterPro:
U6 snRNA-associated Sm-like protein LSm2 in PDB entry 3jcr, assembly 1, front view.
U6 snRNA-associated Sm-like protein LSm2 in PDB entry 3jcr, assembly 1, side view.
U6 snRNA-associated Sm-like protein LSm2 in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

U6 snRNA-associated Sm-like protein LSm7
Chain: 7
Length: 103 amino acids
Theoretical weight: 11.62 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q9UK45 (Residues: 1-103; Coverage: 100%)
Gene name: LSM7
Pfam: LSM domain
InterPro:
U6 snRNA-associated Sm-like protein LSm7 in PDB entry 3jcr, assembly 1, front view.
U6 snRNA-associated Sm-like protein LSm7 in PDB entry 3jcr, assembly 1, side view.
U6 snRNA-associated Sm-like protein LSm7 in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

U4/U6 small nuclear ribonucleoprotein Prp3
Chain: K
Length: 683 amino acids
Theoretical weight: 77.67 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O43395 (Residues: 1-683; Coverage: 100%)
Gene names: HPRP3, PRP3, PRPF3
Pfam:
InterPro:
U4/U6 small nuclear ribonucleoprotein Prp3 in PDB entry 3jcr, assembly 1, front view.
U4/U6 small nuclear ribonucleoprotein Prp3 in PDB entry 3jcr, assembly 1, side view.
U4/U6 small nuclear ribonucleoprotein Prp3 in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

U4/U6 small nuclear ribonucleoprotein Prp4
Chain: L
Length: 521 amino acids
Theoretical weight: 58.41 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O43172 (Residues: 1-522; Coverage: 100%)
Gene names: PRP4, PRPF4
Pfam:
InterPro:
U4/U6 small nuclear ribonucleoprotein Prp4 in PDB entry 3jcr, assembly 1, front view.
U4/U6 small nuclear ribonucleoprotein Prp4 in PDB entry 3jcr, assembly 1, side view.
U4/U6 small nuclear ribonucleoprotein Prp4 in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

U4/U6 small nuclear ribonucleoprotein Prp31
Chain: J
Length: 499 amino acids
Theoretical weight: 55.53 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q8WWY3 (Residues: 1-499; Coverage: 100%)
Gene names: PRP31, PRPF31
Pfam:
InterPro:
U4/U6 small nuclear ribonucleoprotein Prp31 in PDB entry 3jcr, assembly 1, front view.
U4/U6 small nuclear ribonucleoprotein Prp31 in PDB entry 3jcr, assembly 1, side view.
U4/U6 small nuclear ribonucleoprotein Prp31 in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

NHP2-like protein 1
Chain: I
Length: 128 amino acids
Theoretical weight: 14.19 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P55769 (Residues: 1-128; Coverage: 100%)
Gene names: NHP2L1, SNU13
Pfam: Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
InterPro:
NHP2-like protein 1 in PDB entry 3jcr, assembly 1, front view.
NHP2-like protein 1 in PDB entry 3jcr, assembly 1, side view.
NHP2-like protein 1 in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

Ubiquitin carboxyl-terminal hydrolase 39
Chain: V
Length: 565 amino acids
Theoretical weight: 65.48 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q53GS9 (Residues: 1-565; Coverage: 100%)
Gene names: CGI-21, HSPC332, PRO2855, USP39
Pfam:
InterPro:
Ubiquitin carboxyl-terminal hydrolase 39 in PDB entry 3jcr, assembly 1, front view.
Ubiquitin carboxyl-terminal hydrolase 39 in PDB entry 3jcr, assembly 1, side view.
Ubiquitin carboxyl-terminal hydrolase 39 in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar proteins

RNA chain M
Name: U4 snRNA
Representative chains: M
Length: 145 nucleotides
Theoretical weight: 46.54 KDa
Rfam: U4 spliceosomal RNA
U4 snRNA in PDB entry 3jcr, assembly 1, front view.
U4 snRNA in PDB entry 3jcr, assembly 1, side view.
U4 snRNA in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar RNA

RNA chain N
Name: U6 snRNA
Representative chains: N
Length: 106 nucleotides
Theoretical weight: 34.1 KDa
Rfam: U6 spliceosomal RNA
U6 snRNA in PDB entry 3jcr, assembly 1, front view.
U6 snRNA in PDB entry 3jcr, assembly 1, side view.
U6 snRNA in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar RNA

RNA chain H
Name: U5 snRNA
Representative chains: H
Length: 116 nucleotides
Theoretical weight: 36.89 KDa
Rfam: U5 spliceosomal RNA
U5 snRNA in PDB entry 3jcr, assembly 1, front view.
U5 snRNA in PDB entry 3jcr, assembly 1, side view.
U5 snRNA in PDB entry 3jcr, assembly 1, top view.
Molecule details ›

Search similar RNA

Quick links