› 3j9l

Electron Microscopy
4Å resolution

Structure of Dark apoptosome from Drosophila melanogaster

Released:
DOI: 10.2210/pdb3j9l/pdb
PDB entry 3j9l coloured by chain, front view.
PDB entry 3j9l coloured by chain, side view.
PDB entry 3j9l coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Structure of the apoptosome: mechanistic insights into activation of an initiator caspase from Drosophila.
Pang Y, Bai XC, Yan C, Hao Q, Chen Z, Wang JW, Scheres SH, Shi Y
Genes Dev 29 277-87 (2015)
PMID: 25644603
Related structures: EMD-2871

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181591 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apaf-1/CED-4-related caspase activator Dapaf-1L Chains: A, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q
Molecule details ›
Chains: A, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q
Length: 1103 amino acids
Theoretical weight: 112.83 KDa
Source organism: Drosophila melanogaster
UniProt:
  • Canonical: Q7KLI1 (Residues: 1-583; Coverage: 41%)
Gene names: APAF-1, APAF1, ARK, Apaf, Apaf-1, Apaf1, Ark, Ark-RB, CG6829, D-Apaf-1, DARK, Dapaf-1, Dapaf-1/HAC-1, Dark, Dark/Apaf-I, Dark/Dapaf-1/HAC1, Dark/Hac-1/dApaf-1, Dark/Hac-1/dApaf1, Dmel\CG6829, Dmel_CG6829, Hac-1, Hac-1/Dark, Hac1, T1, anon-53Fa, apaf-1, apaf1, arc, ark, dAPAF-1, dApaf-1, dApaf-1/DARK/HAC-1, dApaf1, dArk, dapaf, dapaf-1, dapaf-1L, dapaf-1S, dark, dark/dapaf-1/hac-1, dark/hac-1/dapaf-1, hac-1, hac1, l(2)SH0173
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand DTP 15 x DTP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4Å
Relevant EMDB volumes: EMD-2871

Quick links

Citations

4 review citations

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Galluzzi et al. (2018)
3 more

2 mentions without citation

New insights into apoptosome structure and function.
Dorstyn et al. (2018)
1 more