3it8 Citations

Crystal structure of TNFalpha complexed with a poxvirus MHC-related TNF binding protein.

Nat. Struct. Mol. Biol. 16 1189-91 (2009)
Cited: 14 times
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The poxvirus 2L protein binds tumor necrosis factor-alpha (TNFalpha) to inhibit host antiviral and immune responses. The 2.8-A 2L-TNFalpha structure reveals three symmetrically arranged 2L molecules per TNFalpha trimer. 2L resembles class I major histocompatibility complex (MHC) molecules but lacks a peptide-binding groove and beta2-microglobulin light chain. Overlap between the 2L and host TNF receptor-binding sites on TNFalpha rationalizes 2L inhibition of TNFalpha-TNF receptor interactions and prevention of TNFalpha-induced immune responses.

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  2. Structural basis of Flavivirus NS1 assembly and antibody recognition. Edeling MA, Diamond MS, Fremont DH. Proc. Natl. Acad. Sci. U.S.A. 111 4285-4290 (2014)
  3. Structural basis for treating tumor necrosis factor α (TNFα)-associated diseases with the therapeutic antibody infliximab. Liang S, Dai J, Hou S, Su L, Zhang D, Guo H, Hu S, Wang H, Rao Z, Guo Y, Lou Z. J. Biol. Chem. 288 13799-13807 (2013)
  4. A novel bat herpesvirus encodes homologues of major histocompatibility complex classes I and II, C-type lectin, and a unique family of immune-related genes. Zhang H, Todd S, Tachedjian M, Barr JA, Luo M, Yu M, Marsh GA, Crameri G, Wang LF. J. Virol. 86 8014-8030 (2012)
  5. Allosteric competitive inactivation of hematopoietic CSF-1 signaling by the viral decoy receptor BARF1. Elegheert J, Bracke N, Pouliot P, Gutsche I, Shkumatov AV, Tarbouriech N, Verstraete K, Bekaert A, Burmeister WP, Svergun DI, Lambrecht BN, Vergauwen B, Savvides SN. Nat. Struct. Mol. Biol. 19 938-947 (2012)
  6. Structural pathways of cytokines may illuminate their roles in regulation of cancer development and immunotherapy. Guven-Maiorov E, Acuner-Ozbabacan SE, Keskin O, Gursoy A, Nussinov R. Cancers (Basel) 6 663-683 (2014)
  7. Comparative Biochemical and Functional Analysis of Viral and Human Secreted Tumor Necrosis Factor (TNF) Decoy Receptors. Pontejo SM, Alejo A, Alcami A. J. Biol. Chem. 290 15973-15984 (2015)
  8. Discovery of binding proteins for a protein target using protein-protein docking-based virtual screening. Zhang C, Tang B, Wang Q, Lai L. Proteins 82 2472-2482 (2014)
  9. Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF. Felix J, Kandiah E, De Munck S, Bloch Y, van Zundert GC, Pauwels K, Dansercoer A, Novanska K, Read RJ, Bonvin AM, Vergauwen B, Verstraete K, Gutsche I, Savvides SN. Nat Commun 7 13228 (2016)
  10. Rational design of TNFα binding proteins based on the de novo designed protein DS119. Zhu C, Zhang C, Zhang T, Zhang X, Shen Q, Tang B, Liang H, Lai L. Protein Sci. 25 2066-2075 (2016)