Function and Biology

Crystal structure of TNF alpha complexed with a poxvirus MHC-related TNF binding protein

Source organisms:
Biochemical function: peptidase activity
Biological process: protein phosphorylation
Cellular component: membrane

Sequence family

Pfam Protein family (Pfam)
PF00229
Domain description: TNF(Tumour Necrosis Factor) family
Occurring in:
  1. Tumor necrosis factor, soluble form
1 copy of Pfam domain PF00229 (TNF(Tumour Necrosis Factor) family) in Tumor necrosis factor, soluble form in PDB 3it8.

InterPro InterPro annotations
IPR006053
Domain description: Tumour necrosis factor
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR002959
Domain description: Tumour necrosis factor alpha
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR006052
Domain description: Tumour necrosis factor domain
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR008983
Domain description: Tumour necrosis factor-like domain superfamily
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. 2L protein
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. 2L protein
IPR021184
Domain description: Tumour necrosis factor, conserved site
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. 2L protein

Structure domains

CATH CATH domains
2.60.120.40
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. Tumor necrosis factor, soluble form
1 copy of CATH domain 2.60.120.40 (Jelly Rolls) in Tumor necrosis factor, soluble form in PDB 3it8.
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. 2L protein
1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in 2L protein in PDB 3it8.