Structure analysis

Crystal structure of TNF alpha complexed with a poxvirus MHC-related TNF binding protein

X-ray diffraction
2.8Å resolution
Assembly composition:
hetero hexamer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer

Binding statistics and energies are not available for this assembly
Assembly 2
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Multimeric state: hetero hexamer

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: D, E, F, J, K, L
Length: 324 amino acids
Theoretical weight: 37.33 KDa
Source organism: Yaba-like disease virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9DHW0 (Residues: 17-332; Coverage: 94%)
Gene name: 2L
InterPro:
CATH: Immunoglobulins

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Chains: A, B, C, G, H, I
Length: 161 amino acids
Theoretical weight: 17.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01375 (Residues: 82-233; Coverage: 65%)
Gene names: TNF, TNFA, TNFSF2
Pfam: TNF(Tumour Necrosis Factor) family
InterPro:
CATH: Jelly Rolls

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