PDBe 3ips

X-ray diffraction
2.26Å resolution

X-ray structure of benzisoxazole synthetic agonist bound to the LXR-alpha


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Oxysterols receptor LXR-alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 283 amino acids
Theoretical weight: 32.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q13133 (Residues: 182-447; Coverage: 60%)
Gene names: LXRA, NR1H3
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 25 amino acids
Theoretical weight: 2.81 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q15788 (Residues: 676-700; Coverage: 2%)
Gene names: BHLHE74, NCOA1, SRC1

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P4212
Unit cell:
a: 123.051Å b: 123.051Å c: 91.636Å
α: 90° β: 90° γ: 90°
R R work R free
0.258 0.255 0.314
Expression systems:
  • Escherichia coli
  • Not provided