PDBe 3iok

X-ray diffraction
2.1Å resolution

2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase JAK2 Chain: A
Molecule details ›
Chain: A
Length: 313 amino acids
Theoretical weight: 36.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O60674 (Residues: 842-1132; Coverage: 26%)
Gene name: JAK2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2221
Unit cell:
a: 93.512Å b: 102.546Å c: 67.602Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.224 0.27
Expression system: Spodoptera frugiperda