PDBe 3inx

X-ray diffraction
1.75Å resolution

HSP90 N-TERMINAL DOMAIN with pochoxime B

Released:

Function and Biology Details

Reaction catalysed:
ATP + H(2)O = ADP + phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein HSP 90-alpha Chain: A
Molecule details ›
Chain: A
Length: 228 amino acids
Theoretical weight: 25.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07900 (Residues: 10-236; Coverage: 31%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Structure domains: Heat Shock Protein 90

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: I222
Unit cell:
a: 67.2Å b: 89.618Å c: 98.385Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.168 0.217
Expression system: Escherichia coli