› › Structure analysis

Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pTyr-Ile-Asn-NH2 Tripeptide Mimic

X-ray diffraction
1.7Å resolution
PDB entry 3in8 coloured by chain, front view.
PDB entry 3in8 coloured by chain, side view.
PDB entry 3in8 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Growth factor receptor-bound protein 2
hide full assembly name
Multimeric state: homo dimer
Accessible surface area: 10261.2 Å2
Buried surface area: 2731.57 Å2
Dissociation area: 1,173.61 Å2
Dissociation energy (ΔGdiss): 11.89 kcal/mol
Dissociation entropy (TΔSdiss): 11.35 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-158872

Macromolecules

Growth factor receptor-bound protein 2
Chain: A
Length: 117 amino acids
Theoretical weight: 13.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62993 (Residues: 53-163; Coverage: 51%)
Gene names: ASH, GRB2
Pfam: SH2 domain
InterPro:
CATH: SH2 domain
Growth factor receptor-bound protein 2 in PDB entry 3in8, assembly 1, front view.
Growth factor receptor-bound protein 2 in PDB entry 3in8, assembly 1, side view.
Growth factor receptor-bound protein 2 in PDB entry 3in8, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links