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Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with BMS-754807 [1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-N-(6-fluoro-3-pyridinyl)-2-methyl-L-prolinamide]

X-ray diffraction
2.08Å resolution
PDB entry 3i81 coloured by chain, front view.
PDB entry 3i81 coloured by chain, side view.
PDB entry 3i81 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Insulin-like growth factor 1 receptor alpha chain
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Multimeric state: monomeric
Accessible surface area: 14708.35 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-139909

Macromolecules

Insulin-like growth factor 1 receptor beta chain
Chain: A
Length: 315 amino acids
Theoretical weight: 35.91 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08069 (Residues: 982-1286; Coverage: 23%)
Gene name: IGF1R
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Insulin-like growth factor 1 receptor beta chain in PDB entry 3i81, assembly 1, front view.
Insulin-like growth factor 1 receptor beta chain in PDB entry 3i81, assembly 1, side view.
Insulin-like growth factor 1 receptor beta chain in PDB entry 3i81, assembly 1, top view.
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