Structure analysis

Crystal structure of PI3K SH3

X-ray diffraction
3Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 4800 Å2
Buried surface area: 100 Å2
Dissociation area: 50 Å2
Dissociation energy (ΔGdiss): 2 kcal/mol
Dissociation entropy (TΔSdiss): 1 kcal/mol
Interface energy (ΔGint): -3 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: monomeric

Binding statistics and energies are not available for this assembly
Assembly 3
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Multimeric state: monomeric

Binding statistics and energies are not available for this assembly
Assembly 4
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Multimeric state: monomeric

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: A, B, C, D
Length: 83 amino acids
Theoretical weight: 9.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P27986 (Residues: 1-83; Coverage: 12%)
Gene names: GRB1, PIK3R1
InterPro:
CATH: SH3 Domains

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