PDBe 3i5r

X-ray diffraction
1.7Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptide ligand Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.34 KDa
Source organism: Synthetic construct
Expression system: Not provided
Phosphatidylinositol 3-kinase regulatory subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 83 amino acids
Theoretical weight: 9.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P27986 (Residues: 1-83; Coverage: 12%)
Gene names: GRB1, PIK3R1
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P3121
Unit cell:
a: 60.365Å b: 60.365Å c: 46.525Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.184 0.182 0.223
Expression systems:
  • Not provided
  • Escherichia coli