› › Function and Biology

The crystal structure of the D-alanyl-alanine synthetase A from Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Source organism: Salmonella enterica subsp. enterica serovar Typhimurium
Biochemical function: metal ion binding
Biological process: cell wall organization
Cellular component: cytosol

Quick links

EC 6.3.2.4: D-alanine--D-alanine ligase

Reaction catalysed:
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine
Systematic name:
D-alanine:D-alanine ligase (ADP-forming)
Alternative Name(s):
  • Alanine:alanine ligase (ADP-forming)
  • Alanylalanine synthetase
  • D-Ala-D-Ala synthetase
  • D-alanyl-D-alanine synthetase
  • D-alanylalanine synthetase
  • MurE synthetase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF07478
Domain description: D-ala D-ala ligase C-terminus
Occurring in:
  1. D-alanine--D-alanine ligase A
The deposited structure of PDB entry 3i12 contains 4 copies of Pfam domain PF07478 (D-ala D-ala ligase C-terminus) in D-alanine--D-alanine ligase A. Showing 1 copy in chain A.

PF01820
Domain description: D-ala D-ala ligase N-terminus
Occurring in:
  1. D-alanine--D-alanine ligase A
The deposited structure of PDB entry 3i12 contains 4 copies of Pfam domain PF01820 (D-ala D-ala ligase N-terminus) in D-alanine--D-alanine ligase A. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005905
Domain description: D-alanine--D-alanine ligase
Occurring in:
  1. D-alanine--D-alanine ligase A
IPR000291
Domain description: D-alanine--D-alanine ligase/VANA/B/C, conserved site
Occurring in:
  1. D-alanine--D-alanine ligase A
IPR013815
Domain description: ATP-grasp fold, subdomain 1
Occurring in:
  1. D-alanine--D-alanine ligase A
IPR011095
Domain description: D-alanine--D-alanine ligase, C-terminal
Occurring in:
  1. D-alanine--D-alanine ligase A
IPR011761
Domain description: ATP-grasp fold
Occurring in:
  1. D-alanine--D-alanine ligase A
IPR011127
Domain description: D-alanine--D-alanine ligase, N-terminal domain
Occurring in:
  1. D-alanine--D-alanine ligase A
IPR016185
Domain description: Pre-ATP-grasp domain superfamily
Occurring in:
  1. D-alanine--D-alanine ligase A

Structure domains

CATH CATH domains
3.30.470.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: D-amino Acid Aminotransferase; Chain A, domain 1
Homology: ATP-grasp fold, B domain
Occurring in:
  1. D-alanine--D-alanine ligase A
The deposited structure of PDB entry 3i12 contains 4 copies of CATH domain 3.30.470.20 (D-amino Acid Aminotransferase; Chain A, domain 1) in D-alanine--D-alanine ligase A. Showing 1 copy in chain A.
3.30.1490.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Dna Ligase; domain 1
Homology: ATP-grasp fold, A domain
Occurring in:
  1. D-alanine--D-alanine ligase A
The deposited structure of PDB entry 3i12 contains 4 copies of CATH domain 3.30.1490.20 (Dna Ligase; domain 1) in D-alanine--D-alanine ligase A. Showing 1 copy in chain A.
3.40.50.20
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. D-alanine--D-alanine ligase A
The deposited structure of PDB entry 3i12 contains 4 copies of CATH domain 3.40.50.20 (Rossmann fold) in D-alanine--D-alanine ligase A. Showing 1 copy in chain A.

Quick links