PDBe 3hzf

X-ray diffraction
2.5Å resolution

Structure of TR-alfa bound to selective thyromimetic GC-1 in C2 space group


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Thyroid hormone receptor alpha Chain: A
Molecule details ›
Chain: A
Length: 269 amino acids
Theoretical weight: 31.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P10827 (Residues: 148-370; Coverage: 46%)
  • Best match: P10827-2 (Residues: 148-410)
Gene names: EAR7, ERBA1, NR1A1, THRA, THRA1, THRA2
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU ULTRAX 18
Spacegroup: C2
Unit cell:
a: 89.799Å b: 78.777Å c: 43.071Å
α: 90° β: 95.17° γ: 90°
R R work R free
0.192 0.188 0.263
Expression system: Escherichia coli