PDBe 3hwn

X-ray diffraction
2.33Å resolution

CATHEPSIN L with AZ13010160

Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Cathepsin L1 heavy chain Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 258 amino acids
Theoretical weight: 28.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P07711 (Residues: 76-333; Coverage: 82%)
Gene names: CTSL, CTSL1
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P1
Unit cell:
a: 57.07Å b: 62.8Å c: 67.97Å
α: 105.34° β: 94.04° γ: 115.26°
R R work R free
0.252 0.25 0.347
Expression system: Escherichia coli