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Transthyretin in complex with a covalent small molecule kinetic stabilizer

Source organism: Homo sapiens
Biochemical function: thyroid hormone binding
Biological process: signal transduction
Cellular component: extracellular exosome

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF00576
Domain description: HIUase/Transthyretin family
Occurring in:
  1. Transthyretin
The deposited structure of PDB entry 3hj0 contains 2 copies of Pfam domain PF00576 (HIUase/Transthyretin family) in Transthyretin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000895
Domain description: Transthyretin/hydroxyisourate hydrolase
Occurring in:
  1. Transthyretin
IPR023416
Domain description: Transthyretin/hydroxyisourate hydrolase domain
Occurring in:
  1. Transthyretin
IPR036817
Domain description: Transthyretin/hydroxyisourate hydrolase domain superfamily
Occurring in:
  1. Transthyretin
IPR023419
Domain description: Transthyretin, conserved site
Occurring in:
  1. Transthyretin
IPR023418
Domain description: Transthyretin, thyroxine binding site
Occurring in:
  1. Transthyretin

Structure domain

CATH CATH domain
2.60.40.180
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Transthyretin/hydroxyisourate hydrolase domain
Occurring in:
  1. Transthyretin
The deposited structure of PDB entry 3hj0 contains 2 copies of CATH domain 2.60.40.180 (Immunoglobulin-like) in Transthyretin. Showing 1 copy in chain A.

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