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Crystal structure of intermediate affinity I domain of integrin LFA-1 with the Fab fragment of its antibody AL-57

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00092
Domain description: von Willebrand factor type A domain
Occurring in:
  1. Integrin alpha-L
The deposited structure of PDB entry 3hi6 contains 2 copies of Pfam domain PF00092 (von Willebrand factor type A domain) in Integrin alpha-L. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. Heavy chain of Fab fragment of AL-57 against alpha L I domain
  2. light chain of Fab fragment of AL-57 against alpha L I domain
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Heavy chain of Fab fragment of AL-57 against alpha L I domain
  2. light chain of Fab fragment of AL-57 against alpha L I domain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Heavy chain of Fab fragment of AL-57 against alpha L I domain
  2. light chain of Fab fragment of AL-57 against alpha L I domain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Heavy chain of Fab fragment of AL-57 against alpha L I domain
  2. light chain of Fab fragment of AL-57 against alpha L I domain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Heavy chain of Fab fragment of AL-57 against alpha L I domain
  2. light chain of Fab fragment of AL-57 against alpha L I domain
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. Heavy chain of Fab fragment of AL-57 against alpha L I domain
  2. light chain of Fab fragment of AL-57 against alpha L I domain
IPR002035
Domain description: von Willebrand factor, type A
Occurring in:
  1. Integrin alpha-L
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. Heavy chain of Fab fragment of AL-57 against alpha L I domain
  2. light chain of Fab fragment of AL-57 against alpha L I domain
IPR036465
Domain description: von Willebrand factor A-like domain superfamily
Occurring in:
  1. Integrin alpha-L

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Heavy chain of Fab fragment of AL-57 against alpha L I domain
  2. light chain of Fab fragment of AL-57 against alpha L I domain
The deposited structure of PDB entry 3hi6 contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Heavy chain of Fab fragment of AL-57 against alpha L I domain. Showing 2 copies in chain E [auth X].
The deposited structure of PDB entry 3hi6 contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in light chain of Fab fragment of AL-57 against alpha L I domain. Showing 2 copies in chain D [auth L].
3.40.50.410
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: von Willebrand factor, type A domain
Occurring in:
  1. Integrin alpha-L
The deposited structure of PDB entry 3hi6 contains 2 copies of CATH domain 3.40.50.410 (Rossmann fold) in Integrin alpha-L. Showing 1 copy in chain A.

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