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Germline-governed recognition of a cancer epitope by an immunodominant human T cell receptor

X-ray diffraction
3Å resolution
PDB entry 3hg1 coloured by chain, front view.
PDB entry 3hg1 coloured by chain, side view.
PDB entry 3hg1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero pentamer (preferred)
Entry contents: 5 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero pentamer
Accessible surface area: 37501.0 Å2
Buried surface area: 11410.36 Å2
Dissociation area: 1,163.85 Å2
Dissociation energy (ΔGdiss): 2.82 kcal/mol
Dissociation entropy (TΔSdiss): 13.9 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-134739

Macromolecules

Ig-like domain-containing protein
Chain: A
Length: 276 amino acids
Theoretical weight: 31.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WLS4 (Residues: 25-300; Coverage: 94%)
Gene name: HLA-A
Pfam:
InterPro:
CATH:
Ig-like domain-containing protein in PDB entry 3hg1, assembly 1, front view.
Ig-like domain-containing protein in PDB entry 3hg1, assembly 1, side view.
Ig-like domain-containing protein in PDB entry 3hg1, assembly 1, top view.
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Beta-2-microglobulin
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Beta-2-microglobulin in PDB entry 3hg1, assembly 1, front view.
Beta-2-microglobulin in PDB entry 3hg1, assembly 1, side view.
Beta-2-microglobulin in PDB entry 3hg1, assembly 1, top view.
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Melanoma antigen recognized by T-cells 1
Chain: C
Length: 10 amino acids
Theoretical weight: 985 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q16655 (Residues: 26-35; Coverage: 9%)
Gene names: MART1, MLANA
Melanoma antigen recognized by T-cells 1 in PDB entry 3hg1, assembly 1, front view.
Melanoma antigen recognized by T-cells 1 in PDB entry 3hg1, assembly 1, side view.
Melanoma antigen recognized by T-cells 1 in PDB entry 3hg1, assembly 1, top view.
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T cell receptor alpha chain constant
Chain: D
Length: 194 amino acids
Theoretical weight: 21.37 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01848 (Residues: 1-85; Coverage: 61%)
Gene names: TCRA, TRAC
Pfam: Domain of unknown function (DUF1968)
InterPro:
CATH: Immunoglobulins
T cell receptor alpha chain constant in PDB entry 3hg1, assembly 1, front view.
T cell receptor alpha chain constant in PDB entry 3hg1, assembly 1, side view.
T cell receptor alpha chain constant in PDB entry 3hg1, assembly 1, top view.
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T cell receptor beta constant 1
Chain: E
Length: 244 amino acids
Theoretical weight: 27.26 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01850 (Residues: 1-129; Coverage: 73%)
Gene name: TRBC1
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
T cell receptor beta constant 1 in PDB entry 3hg1, assembly 1, front view.
T cell receptor beta constant 1 in PDB entry 3hg1, assembly 1, side view.
T cell receptor beta constant 1 in PDB entry 3hg1, assembly 1, top view.
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