› 3hf1

X-ray diffraction
2.6Å resolution

Crystal structure of human p53R2

Released:
DOI: 10.2210/pdb3hf1/pdb
PDB entry 3hf1 coloured by chain, front view.
PDB entry 3hf1 coloured by chain, side view.
PDB entry 3hf1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
2.6 A X-ray crystal structure of human p53R2, a p53-inducible ribonucleotide reductase .
Smith P, Zhou B, Ho N, Yuan YC, Su L, Tsai SC, Yen Y
Biochemistry 48 11134-41 (2009)
PMID: 19728742

Function and Biology Details

Reaction catalysed: 
2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H(2)O = ribonucleoside diphosphate + thioredoxin
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181651 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribonucleoside-diphosphate reductase subunit M2 B Chains: A, B
Molecule details ›
Chains: A, B
Length: 351 amino acids
Theoretical weight: 40.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7LG56 (Residues: 1-351; Coverage: 100%)
Gene names: P53R2, RRM2B
Sequence domains: Ribonucleotide reductase, small chain
Structure domains: Ribonucleotide Reductase, subunit A

Ligands and Environments

2 bound ligands:
Ligand FE 3 x FE
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P212121
Unit cell:
a: 68.675Å b: 99.546Å c: 132.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.221 0.273
Expression system: Escherichia coli

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Citations

7 review citations

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Torti et al. (2013)
6 more

13 mentions without citation

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Das et al. (2023)
12 more