PDBe 3h9o

X-ray diffraction
2.3Å resolution

Phosphoinositide-dependent protein kinase 1 (PDK-1) in complex with compound 9

Released:
Source organism: Homo sapiens
Primary publication:
Benzo[c][2,7]naphthyridines as inhibitors of PDK-1.
Bioorg. Med. Chem. Lett. 19 5225-8 (2009)
PMID: 19628388

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-phosphoinositide-dependent protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 311 amino acids
Theoretical weight: 35.58 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O15530 (Residues: 48-359; Coverage: 56%)
  • Best match: O15530-2 (Residues: 1-309)
Gene names: PDK1, PDPK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P3221
Unit cell:
a: 123.77Å b: 123.77Å c: 47.116Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.211 0.209 0.256