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A combined crystallographic and molecular dynamics study of cathepsin-L retro-binding inhibitors (compound 14)

X-ray diffraction
2.5Å resolution
PDB entry 3h8c coloured by chain, front view.
PDB entry 3h8c coloured by chain, side view.
PDB entry 3h8c coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Procathepsin L
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-139718
Assembly 2
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Assembly Name: Procathepsin L
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-139718

Macromolecules

Cathepsin L
Chains: A, B
Length: 220 amino acids
Theoretical weight: 24.22 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P07711 (Residues: 114-333; Coverage: 70%)
Gene names: CTSL, CTSL1
Pfam: Papain family cysteine protease
InterPro:
CATH: Cysteine proteinases
Cathepsin L in PDB entry 3h8c, assembly 1, front view.
Cathepsin L in PDB entry 3h8c, assembly 1, side view.
Cathepsin L in PDB entry 3h8c, assembly 1, top view.
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