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Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase

Source organism: Bacillus anthracis str. A2012
Biochemical function: metal ion binding
Biological process: folic acid biosynthetic process
Cellular component: cytosol

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EC 2.5.1.15: Dihydropteroate synthase

Reaction catalysed:
6-hydroxymethyl-7,8-dihydropterin diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate
Systematic name:
6-hydroxymethyl-7,8-dihydropterin-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase
Alternative Name(s):
  • (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase
  • 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase
  • 7,8-dihydropteroate synthase
  • 7,8-dihydropteroate synthetase
  • 7,8-dihydropteroic acid synthetase
  • DHPS
  • Dihydropteroate diphosphorylase
  • Dihydropteroate pyrophosphorylase
  • Dihydropteroate synthetase
  • Dihydropteroic synthetase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00809
Domain description: Pterin binding enzyme
Occurring in:
  1. Dihydropteroate synthase
The deposited structure of PDB entry 3h2c contains 2 copies of Pfam domain PF00809 (Pterin binding enzyme) in Dihydropteroate synthase. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000489
Domain description: Pterin-binding domain
Occurring in:
  1. Dihydropteroate synthase
IPR006390
Domain description: Dihydropteroate synthase domain
Occurring in:
  1. Dihydropteroate synthase
IPR011005
Domain description: Dihydropteroate synthase-like superfamily
Occurring in:
  1. Dihydropteroate synthase
IPR045031
Domain description: Dihydropteroate synthase-like
Occurring in:
  1. Dihydropteroate synthase
IPR038418
Domain description: 6-pyruvoyl tetrahydropterin synthase/QueD superfamily
Occurring in:
  1. Dihydropteroate synthase

Structure domain

CATH CATH domain
3.20.20.20
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Dihydropteroate synthase-like
Occurring in:
  1. Dihydropteroate synthase
The deposited structure of PDB entry 3h2c contains 2 copies of CATH domain 3.20.20.20 (TIM Barrel) in Dihydropteroate synthase. Showing 1 copy in chain B.

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