PDBe 3h0h

X-ray diffraction
1.76Å resolution

human Fyn SH3 domain R96I mutant, crystal form I

Released:
Source organism: Homo sapiens
Entry authors: Dumas C, Strub M-P, Arold ST

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Fyn Chain: A
Molecule details ›
Chain: A
Length: 73 amino acids
Theoretical weight: 8.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06241 (Residues: 73-142; Coverage: 13%)
Gene name: FYN
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P41
Unit cell:
a: 41.907Å b: 41.907Å c: 32.764Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.166 0.222
Expression system: Escherichia coli