› 3gua

X-ray diffraction
3.1Å resolution

Sulfates bound in the vestibule of AChBP

Released:
DOI: 10.2210/pdb3gua/pdb
PDB entry 3gua coloured by chain, front view.
PDB entry 3gua coloured by chain, side view.
PDB entry 3gua coloured by chain, top view.
Source organism: Aplysia californica
Primary publication:
An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductance.
Hansen SB, Wang HL, Taylor P, Sine SM
J Biol Chem 283 36066-70 (2008)
PMID: 18940802

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186694 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Chains: A, B, C, D, E, F, G, H, I, J
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J
Length: 217 amino acids
Theoretical weight: 24.73 KDa
Source organism: Aplysia californica
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8WSF8 (Residues: 18-225; Coverage: 95%)
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain
Structure domains: Neurotransmitter-gated ion-channel ligand-binding domain

Ligands and Environments

1 bound ligand:
Ligand SO4 21 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P41
Unit cell:
a: 98.428Å b: 98.428Å c: 265.568Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.212 0.25
Expression system: Homo sapiens

Quick links

Citations

11 review citations

Binding, activation and modulation of Cys-loop receptors.
Miller et al. (2010)
10 more

4 mentions without citation

Size matters in activation/inhibition of ligand-gated ion channels.
Du et al. (2012)
3 more