› 3ggf

X-ray diffraction
2.35Å resolution

Crystal structure of human Serine/threonine-protein kinase MST4 in complex with an quinazolin

Released:
DOI: 10.2210/pdb3ggf/pdb
PDB entry 3ggf coloured by chain, front view.
PDB entry 3ggf coloured by chain, side view.
PDB entry 3ggf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural comparison of human mammalian ste20-like kinases.
Record CJ, Chaikuad A, Rellos P, Das S, Pike AC, Fedorov O, Marsden BD, Knapp S, Lee WH
PLoS One 5 e11905 (2010)
PMID: 20730082

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-192829 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 26 Chains: A, B
Molecule details ›
Chains: A, B
Length: 301 amino acids
Theoretical weight: 33.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9P289 (Residues: 1-300; Coverage: 72%)
Gene names: MASK, MST4, STK26
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CD 7 x CD
Ligand GVD 2 x GVD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 65.92Å b: 91.25Å c: 108.97Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.219 0.277
Expression system: Escherichia coli

Quick links

Citations

6 review citations

IκB kinase regulation of the TPL-2/ERK MAPK pathway.
Gantke et al. (2012)
5 more

13 mentions without citation

Looking lively: emerging principles of pseudokinase signaling.
Sheetz et al. (2022)
12 more