PDBe 3gc9

X-ray diffraction
2.05Å resolution

The structure of p38beta C119S, C162S in complex with a dihydroquinazolinone inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 370 amino acids
Theoretical weight: 42.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15759 (Residues: 1-364; Coverage: 100%)
Gene names: MAPK11, PRKM11, SAPK2, SAPK2B
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: P21
Unit cell:
a: 39.184Å b: 158.823Å c: 60.874Å
α: 90° β: 91.59° γ: 90°
R-values:
R R work R free
0.224 0.222 0.275
Expression system: Escherichia coli