PDBe 3g33

X-ray diffraction
3Å resolution

Crystal structure of CDK4/cyclin D3

Released:
Source organism: Homo sapiens
Primary publication:
The structure of CDK4/cyclin D3 has implications for models of CDK activation.
Proc. Natl. Acad. Sci. U.S.A. 106 4171-6 (2009)
PMID: 19237555

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
G1/S-specific cyclin-D3 Chains: B, D
Molecule details ›
Chains: B, D
Length: 306 amino acids
Theoretical weight: 34.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P30281 (Residues: 1-292; Coverage: 100%)
Gene name: CCND3
Sequence domains:
Structure domains: Cyclin A; domain 1
Cyclin-dependent kinase 4 Chains: A, C
Molecule details ›
Chains: A, C
Length: 308 amino acids
Theoretical weight: 34.18 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P11802 (Residues: 1-303; Coverage: 100%)
Gene name: CDK4
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P42212
Unit cell:
a: 141.297Å b: 141.297Å c: 143.53Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.283 0.281 0.314
Expression system: Spodoptera frugiperda