PDBe 3g2f

X-ray diffraction
2.35Å resolution

Crystal structure of the kinase domain of bone morphogenetic protein receptor type II (BMPR2) at 2.35 A resolution

Released:
Source organism: Homo sapiens
Entry authors: Chaikuad A, Thangaratnarajah C, Roos AK, Filippakopoulos P, Salah E, Phillips C, Keates T, Fedorov O, Chalk R, Petrie K, Pike ACW, Von Delft F, Arrowsmith CH, Edwards AM, Weigelt J, Bountra C, Knapp S, Bullock A, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bone morphogenetic protein receptor type-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 336 amino acids
Theoretical weight: 38.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13873 (Residues: 189-517; Coverage: 33%)
Gene names: BMPR2, PPH1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments


1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21212
Unit cell:
a: 94.54Å b: 218.793Å c: 44.187Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.208 0.246
Expression system: Escherichia coli