PDBe 3g04

X-ray diffraction
2.55Å resolution

Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Thyrotropin receptor Chain: C
Molecule details ›
Chain: C
Length: 239 amino acids
Theoretical weight: 26.94 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P16473 (Residues: 22-260; Coverage: 32%)
Gene names: LGR3, TSHR
Sequence domains: Leucine rich repeats (6 copies)
Structure domains: Ribonuclease Inhibitor
HUMAN THYROID STIMULATING AUTOANTIBODY M22 HEAVY CHAIN Chain: B
Molecule details ›
Chain: B
Length: 228 amino acids
Theoretical weight: 24.49 KDa
Source organism: Homo sapiens
Expression system: hybrid
Structure domains: Immunoglobulins
HUMAN THYROID STIMULATING AUTOANTIBODY M22 LIGHT CHAIN Chain: A
Molecule details ›
Chain: A
Length: 216 amino acids
Theoretical weight: 23.04 KDa
Source organism: Homo sapiens
Expression system: hybrid
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: I212121
Unit cell:
a: 43.888Å b: 175.784Å c: 205.806Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.181 0.245
Expression systems:
  • Trichoplusia ni
  • hybrid