PDBe 3fxx

X-ray diffraction
1.7Å resolution

Human EphA3 Kinase and Juxtamembrane Region Bound to Substrate KQWDNYE[pTyr]IW

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
peptide substrate Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.53 KDa
Source organism: Synthetic construct
Expression system: Not provided
Ephrin type-A receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 371 amino acids
Theoretical weight: 41.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29320 (Residues: 577-947; Coverage: 39%)
Gene names: EPHA3, ETK, ETK1, HEK, TYRO4
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P21
Unit cell:
a: 53.463Å b: 38.201Å c: 76.649Å
α: 90° β: 102.15° γ: 90°
R-values:
R R work R free
0.168 0.166 0.194
Expression systems:
  • Not provided
  • Escherichia coli