PDBe 3fw3

X-ray diffraction
1.72Å resolution

Crystal Structure of soluble domain of CA4 in complex with Dorzolamide


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Carbonic anhydrase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 266 amino acids
Theoretical weight: 30.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P22748 (Residues: 19-284; Coverage: 91%)
Gene name: CA4
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Carbonic Anhydrase II

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21
Unit cell:
a: 49.991Å b: 70.826Å c: 71.774Å
α: 90° β: 91.91° γ: 90°
R R work R free
0.177 0.176 0.206
Expression system: Escherichia coli