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Crystal Structure of 11b-Hydroxysteroid Dehydrogenase-1 (11b-HSD1) in Complex with Piperidyl Benzamide Inhibitor

Source organism: Homo sapiens
Biochemical function: cortisol dehydrogenase activity
Biological process: lung development
Cellular component: intracellular membrane-bounded organelle

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EC 1.1.1.201: 7-beta-hydroxysteroid dehydrogenase (NADP(+))

Reaction catalysed:
A 7-beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + NADPH
Systematic name:
7-beta-hydroxysteroid:NADP(+) 7-oxidoreductase
Alternative Name(s):
  • NADP-dependent 7-beta-hydroxysteroid dehydrogenase

EC 1.1.1.146: 11-beta-hydroxysteroid dehydrogenase

Reaction catalysed:
An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH
Systematic name:
11-beta-hydroxysteroid:NADP(+) 11-oxidoreductase
Alternative Name(s):
  • 11-beta-hydroxy steroid dehydrogenase
  • Beta-hydroxysteroid dehydrogenase
  • Corticosteroid 11-beta-dehydrogenase
  • Corticosteroid 11-reductase
  • Dehydrogenase, 11-beta-hydroxy steroid

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00106
Domain description: short chain dehydrogenase
Occurring in:
  1. 11-beta-hydroxysteroid dehydrogenase 1
The deposited structure of PDB entry 3frj contains 2 copies of Pfam domain PF00106 (short chain dehydrogenase) in 11-beta-hydroxysteroid dehydrogenase 1. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR002347
Domain description: Short-chain dehydrogenase/reductase SDR
Occurring in:
  1. 11-beta-hydroxysteroid dehydrogenase 1
IPR020904
Domain description: Short-chain dehydrogenase/reductase, conserved site
Occurring in:
  1. 11-beta-hydroxysteroid dehydrogenase 1
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. 11-beta-hydroxysteroid dehydrogenase 1

Structure domain

CATH CATH domain
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. 11-beta-hydroxysteroid dehydrogenase 1
The deposited structure of PDB entry 3frj contains 2 copies of CATH domain 3.40.50.720 (Rossmann fold) in 11-beta-hydroxysteroid dehydrogenase 1. Showing 1 copy in chain B.

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