› 3fq7

X-ray diffraction
2.15Å resolution

Gabaculine complex of GSAM

Released:
DOI: 10.2210/pdb3fq7/pdb
PDB entry 3fq7 coloured by chain, front view.
PDB entry 3fq7 coloured by chain, side view.
PDB entry 3fq7 coloured by chain, top view.
Source organism: Synechococcus elongatus PCC 6301
Primary publication:
Absence of a catalytic water confers resistance to the neurotoxin gabaculine.
Orriss GL, Patel TR, Sorensen J, Stetefeld J
FASEB J 24 404-14 (2010)
PMID: 19786580

Function and Biology Details

Reaction catalysed: 
(S)-4-amino-5-oxopentanoate = 5-aminolevulinate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150263 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate-1-semialdehyde 2,1-aminomutase Chains: A, B
Molecule details ›
Chains: A, B
Length: 427 amino acids
Theoretical weight: 45.59 KDa
Source organism: Synechococcus elongatus PCC 6301
UniProt:
  • Canonical: P24630 (Residues: 7-433; Coverage: 99%)
Gene names: gsa, hemL, syc0881_c
Sequence domains: Aminotransferase class-III
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand PXG 2 x PXG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 66.372Å b: 107.025Å c: 121.752Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.24

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Citations

2 review citations

Structure and function of enzymes in heme biosynthesis.
Layer et al. (2010)
1 more