PDBe 3fpq

X-ray diffraction
1.8Å resolution

Crystal structure of the kinase domain of WNK1

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase WNK1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 290 amino acids
Theoretical weight: 33.9 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9JIH7 (Residues: 194-483; Coverage: 14%)
Gene names: Hsn2, Prkwnk1, Wnk1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P1
Unit cell:
a: 38.308Å b: 57.767Å c: 65.657Å
α: 91.32° β: 89.99° γ: 90.88°
R-values:
R R work R free
0.19 0.188 0.223
Expression system: Escherichia coli