PDBe 3fpm

X-ray diffraction
3.3Å resolution

Crystal Structure of a Squarate Inhibitor bound to MAPKAP Kinase-2

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo 12-mer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MAP kinase-activated protein kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 325 amino acids
Theoretical weight: 37.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49137 (Residues: 41-364; Coverage: 81%)
Gene name: MAPKAPK2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: F4132
Unit cell:
a: 254.658Å b: 254.658Å c: 254.658Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.284 0.282 0.337
Expression system: Escherichia coli