PDBe 3fnt

X-ray diffraction
3.3Å resolution

Crystal structure of pepstatin A bound histo-aspartic protease (HAP) from Plasmodium falciparum

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero tetramer
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
HAP protein Chain: A
Molecule details ›
Chain: A
Length: 332 amino acids
Theoretical weight: 37.44 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IM15 (Residues: 120-451; Coverage: 74%)
Gene names: PF14_0078, PF3D7_1408100
Sequence domains: Eukaryotic aspartyl protease
Structure domains: Acid Proteases
Inhibitor, (IVA)VV(STA)A(STA) Chain: I
Molecule details ›
Chain: I
Length: 6 amino acids
Theoretical weight: 686 Da
Source organism: Streptomyces argenteolus subsp. toyonakensis
Expression system: Not provided

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P3221
Unit cell:
a: 70.7Å b: 70.7Å c: 158.7Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.288 0.285 0.353
Expression systems:
  • Escherichia coli
  • Not provided