PDBe 3fln

X-ray diffraction
1.9Å resolution

P38 kinase crystal structure in complex with R1487

Released:
Source organism: Homo sapiens
Entry authors: Kuglstatter A, Knapp M

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: C
Molecule details ›
Chain: C
Length: 372 amino acids
Theoretical weight: 42.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16539 (Residues: 1-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 45.699Å b: 85.88Å c: 124.793Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.21 0.234
Expression system: Escherichia coli